1Department of Orthopedic Surgery,Baise People′s Hospital,Southwest Hospital Affiliated to Youjiang Medical University for Nationalities，Baise 533000,China；2Department of Clinical Laboratory,Guigang Traditional Chinese and Western Medicine Department of Orthopedics Hospital,Guigang Red Cross Hospital，Guigang 537100,China
Abstract：ObjectiveTo explore the clinical effect of methylcobalamin in combination with rat nerve growth factor on the treatment of traumatic peripheral nerve injury.MethodsOne hundred cases of patients with peripheral nerve injury from Baise People′s Hospital were enrolled from January 2012 to January 2015.All patients were not suffering from other nervous system disease before the injury and were divided into the treatment group (a joint model NGF-methylcobalamin group，50 cases) and control group (a-methylcobalamin group，50 cases) by simple random grouping method.Pain，numbness symptoms improved and the improvement of neural electrophysiological changes were compared between the two groups 1 and 3 months after treatment.ResultsCompared with control group，pain，feel numbness symptoms of treatment group were significantly decreased，and pain symptoms effectiveness of the two groups were 56%(28/50)，94%(47/50) respectively，the difference was significant （χ2=19.25,P<0.01).Feel numb symptom effectiveness were 64%(32/50)，88%(44/50) respectively，the difference was significant （χ2=19.95,P<0.01).Incubation periods of sensory ［(5.95±0.80)ms］ and motor ［(5.40±1.20)ms］ nerve recovery potential of treatment group were significantly less than those of the control group ［（11.10±1.55)ms,(9.92±1.40)ms］，the differences were statistically significant (t=20.84，17.33;P<0.01).Amplitudes of sensory ［（9.55±1.60）mV］ and motor ［（10.10±2.30）mV］ nerve potential of the treatment group were significantly higher than those of control group ［（5.05±1.70）mV,（5.77±1.50）mV］，the differences were statistically significant (t=13.63,11.15;P<0.01).ConclusionThe effect of methylcobalamin in combination with rat NGF on the treatment of traumatic peripheral nerve injury is satisfactory,it is worth promoting.
