Abstract：ObjectiveTo investigate the diagnostic features and treatment of primary thyroid lymphoma with diffuse large B lymphocyte （DLCBL）．MethodsOne patient of primary thyroid lymphoma with diffuse large B lymphocyte was diagnosed.The related literatures were reviewed．ResultsA nodule with diameter of 6cm could be touched in the left lobe of thyroid with the patient.Thymoglobulin antibody was positive,and the levels of other thyroid hormones were normal.The level of Ferritin was 372ng/ml.The lymph nodes were detected on the left neck and right supraclavicular with ultrasound.Multiple lymph nodes enlargement and calcification were found in the right hilum and mediastinum.DLCBL(Stage ⅡA) in the left thyroid originated from germinal center with pathological examination.Cluster of differentiation 20（CD20）,B cell specific active protein-5（PAX-5）,CD10,B cell lymphoma-6 gene（BCL-6）,B cell lymphoma-2 gene （BCL-2）,Multiple myeloma oncogene1 （MUM-1）,c-myc were positive by immunohistochemistry.Meanwhile,bone marrow biopsy and bone marrow pathology showed，CD3,CD5 were positive in T lymphocytes.CD30,anaplastic lymphoma kinase (ALK) were negative.Ki 67 was about 85%.CD10,CD20,CD5,CD38 were occasionally positive.MUM-1,BCL6,CyclinD1 were negative.Ki 67 was not clearly located.The immunophenotype of lymphocytes were normal with flow cytometry.ConclusionsDiffuse large B cell lymphoma located in thyroid is one of the rare lymphomas.An optional protocol is based on precision diagnosis according to pathological characteristics and other imageological examinations.
