Abstract：Objectives To explore the changes of cognitive function and potential in patients with medication-overuse headache (MOH). Methods The subjects were divided into two groups: observation group (patients with MOH, n=30) and control group (n=30). P300 was used to detect the cognitive potential and mini mental state examination (MMSE) was performed to evaluate the cognitive function of the subjects. Results The differences between the two groups were significant.The P3 latency in observation group [(393.70±42.60) ms] was more prolonged than that in the control group (331.05±22.35) ms].The difference between the two groups was significant(t=7.13,P<0.05);The amplitudes of P3 in observation group [(3.40±2.30)uV],was lower than that in the control group[ (6.20±2.40)uV].The difference between the two groups was also significant(t=4.59,P<0.05).The MMSE in observation group were shown as follows: total score (24.00±2.21), orientation (8.15±0.86), anamnesis (2.88±0.23),calculation (3.07±1.04), recall (1.72±0.89) and language (8.42±1.33). In control group, the MMSE were shown as total score (27.07±2.06),orientation (9.28±1.03), anamnesis (3.01±0.26), calculation (3.25±1.20), recall (1.92±0.90) and language (9.69±1.44). The differences between the two groups were all significant 公式,3.19,3.34,P<0.01). Conclusion The patients with MOH had the mild cognitive impairment, and P300 cognitive potential could provideObjective indicators for the diagnosis of cognitive dysfunction of patients with MOH.
徐存理 刘洪强 文庆贤 王瑞科. 药物滥用性头痛患者认知功能及事件相关电位P300的研究[J]. 中华诊断学电子杂志, 2014, 2(1): 58-60.
Xu Cunli*,Liu Hongqiang,Wen Qingxian,Wang Ruike. Clinical research of the cognitive function and event-related potential P300 in patients with medication-overuse headache. zhzdx, 2014, 2(1): 58-60.
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