Thinking of the relationship between neuroendocrine responses and clinical diagnosis as well as therapy in the early phase of trauma
Yang Ce，Du Juan，Wang Haiyan，Yang Xuetao，Jiang Jianxin
Department of State Key Laboratory of Trauma,Burns and Combined Injury,Institute of Surgery Research,Third Military Medical University,Chongqing 400042,China
Abstract：During the occurrence and development of wounds,the neurosecretory and immune systems act as a prominent leader navigator and possess an intrinsic crosstalk in the reciprocal information dissemination.The fundamental reason is that neuroendocrinology and immunology could mix with each other and permeate mutually.It is owing to their same biological languages or chemical information molecules (hormones,neurotransmitters,neuropeptides,cytokines and their corresponding receptors) shared by the neuroendocrine and immune systems.The immune system is modulated by the neuroendocrine system,and can modulate the biological functions of neuroendocrine system at the same time.The interactive linkage of these three systems precipitates the complicated space-time patterns for the courses of traumatic infections.Recently compelling evidences indicated that the network linkage pattern with neuroendocrine responses as initiating agents,immune cells as regulatory elements and immune regulatory molecules as effector targets arouse immune dysfunction after trauma,which supplies the beneficial enlightenment for the clinical diagnosis and therapy concerning the view of translation medicine.
杨策 杜娟 王海燕 杨学涛 蒋建新. 神经内分泌反应与创伤感染早期诊治关系的思考[J]. 中华诊断学电子杂志, 2015, 3(2): 118-121.
Yang Ce，Du Juan，Wang Haiyan，Yang Xuetao，Jiang Jianxin. Thinking of the relationship between neuroendocrine responses and clinical diagnosis as well as therapy in the early phase of trauma. zhzdx, 2015, 3(2): 118-121.
