Abstract：Chronic obstructive pulmonary disease(COPD) is a common lung disease in clinic,and its acute exacerbation (AECOPD) is one of the important cause of death in the elderly.Earlier diagnosis and treatment is vital for preventing the development of diseases and improving prognosis.Studies have shown that AECOPD may be related to protease-antiprotease imbalances,oxidative stress,inflammation,and cell damage and so on,so the study of related biomarkers can help assess the severity and the treatment of the illness.Innovative sampling techniques which mainly include non-invasive,semi-invasive and invasive methods have led to the identification of several pulmonary biomarkers in the past decade.Pulmonary biomarkers are sampled in the exhaled air,exhaled breath condensate,spontaneous sputum,induced sputum,bronchoalveolar lavage fluid and lung biopsies.This article try to highlight the reciprocal links and illustrate the clinical effects of these biomarkers,expecting to contribute to the more significant clinical assessment in AECOPD and provide more references for treatment options.
郭凯1殷少军2. 慢性阻塞性肺疾病急性加重期相关生物标志物及其诊断意义[J]. 中华诊断学电子杂志, 2015, 3(2): 133-137.
Guo Kai1,Yin Shaojun2. Progress and diagnostic value of related biomarkers in acute exacerbation of chronic obstructive pulmonary disease. zhzdx, 2015, 3(2): 133-137.
