Abstract：ObjectiveTo investigate the value of hydrogen proton magnetic resonance spectroscopy (1H-MRS) in the differential diagnosis of amnestic mild cognitive impairment (aMCI) and non-amnestic mild cognitive impairment (naMCI).MethodsTwenty-five cases of aMCI patients were enrolled,twenty-two cases with naMCI and twenty subjects were elderly with normal cognitive function (NC).They all received examination of 1H-MRS.The regions of interest were examined,including the left hippocampus,the posterior cingulate gyrus,and the frontal lobes.The area under the peak was determined for N-acethyl aspartate (NAA),glutamate (Glu),inositol (mI) and creatine (Cr).The ratios of NAA/Cr,Glu/Cr and mI/Cr were compared in different brain regions among the three groups with SPSS17.0.ResultsCompared with the NC group,the ratio of NAA/Cr in the left hippocampus group was significantly lower than that in the aMCI and naMCI groups (1.09±0.11,1.07±0.08,1.20±0.21;t=0.247,0.312;all P<0.05),and the ratio of NAA/Cr in the left posterior cingulate gyrus group was also significantly reduced with those in the aMCI and naMCI groups (1.02±0.09,1.07±0.10,1.22±0.18;t=0.442,0.381;all P<0.05).However,no significant difference in the ratio of NAA/Cr in any brain region were observed between aMCI and naMCI groups (t=0.021,0.036;P>0.05).The Glu/Cr ratio in the posterior cingulate gyrus of the aMCI group decreased significantly compared with that in the naMCI and NC groups (0.35±0.04,0.43±0.02,0.42±0.05;t=0.474,0.405;all P<0.05).No significant difference in the Glu/Cr ratio was observed in other brain regions among the three groups (F=0.382,0.363；all P>0.05).The mI/Cr ratio in the hippocampus was significantly bigger in the aMCI group than that in the naMCI and NC groups (0.66±0.07,0.39±0.04,0.41±0.04;t=0.293,0.247;all P<0.05),and the mI/Cr ratio in the posterior cingulate gyrus was also significantly higher in the aMCI group than that in the naMCI and NC groups (0.62±0.05,0.42±0.03,0.44±0.04;t=0.255,0.261;all P<0.05).The mI/Cr ratio in the frontal lobes of the naMCI group increased significantly compared with that in the aMCI and NC groups(0.58±0.04,0.43±0.03,0.41±0.03;t=0.174,0.226;all P<0.05).ConclusionsRegional differences of mI and Glu metabolism are found in brain tissues of patients with aMCI and naMCI.1H-MRS is an effective method in the differential diagnosis of aMCI and naMCI.
陈双庆 蔡庆 沈玉英 许传虓. 磁共振波谱在遗忘型与非遗忘型轻度认知障碍鉴别诊断中的应用价值[J]. 中华诊断学电子杂志, 2015, 3(3): 159-163.
Chen Shuangqing,Cai Qing,Shen Yuying,Xu Chuanxiao. The value of hydrogen proton magnetic resonance spectroscopy in the differential diagnosis of amnestic and non-amnestic mild cognitive impairment. zhzdx, 2015, 3(3): 159-163.
