Abstract：ObjectiveTo explore the change of immune function and the effect of Adrenocorticotropic hormone (ACTH) on lymphocyte subsets in children with infantile spasm. MethodsTwenty-five cases with newly diagnosed infantile spasm were gathered from November 2012 to September 2014,while another twenty-one healthy cases were chosen as normal control group.ACTH was administered for 4 weeks.Sera was sampled for analyses of the counts of CD3+,CD4+ and CD8+ before and after 4 weeks of treatment,and the results were compared with those of the controls.ResultsCompared to the controls,the count of CD3+T cell in patients demonstrated significant decreasement ［patients:(64.2±7.5)%,controls:(70.2±8.4)%,t=2.53%,P<0.05］.The count of CD4+T cell in patients demonstrated significant reduction ［patients：(38.7±4.8)%,controls:(46.8±5.7)%,t=5.15,P<0.05］.The count of CD8+T cell had no statistically significant differences between patients and controls ［patients:(35.6±5.7)%,controls:(34.4±4.9)%,t=0.77,P>0.05］.The ratio of CD4+/CD8+T cell in patients demonstrated significant decrease ［patients:1.4±0.3,controls:1.7±0.5,t=2.41,P<0.05］.The count of CD3+T cell in patients had no statistically significant differences before and after treatment ［before treatment:(64.2±7.5)%,after treatment:(64.9±8.6)%,t=0.32,P>0.05］.The count of CD4+T cell in patients had no statistically significant differences before and after treatment ［before treatment:(38.7±4.8)%,after treatment:(39.2±4.6)%,t=0.41,P>0.05］.The count of CD8+T cell in patients had no statistically significant differences before and after treatment (before treatment:(35.6±5.7)%,after treatment:(35.9±5.9)%,t=0.21,P>0.05).The ratio of CD4+/CD8+T cell in patients had no statistically significant differences before and after treatment (before treatment:1.4±0.3,after treatment:1.5±0.5,t=0.80,P>0.05).ConclusionsChildren with infantile spasm have immunological alterations,and ACTH has no effect on lymphocyte subsets.ACTH may not regulate the cellular immune function of children with infantile spasm.
李秋波1蔡文仙1褚旭2孔庆霞2朱翠平1. 促肾上腺皮质激素对婴儿痉挛症患儿淋巴细胞亚群的影响[J]. 中华诊断学电子杂志, 2015, 3(3): 198-200.
Li Qiubo1,Cai Wenxian1,Chu Xu2,Kong Qingxia2，Zhu Cuiping1. Effect of Adrenocorticotropic hormone on lymphocyte subsets in children with infantile spasms. zhzdx, 2015, 3(3): 198-200.
