1Department of Nuclear Medicine,Affiliated Hospital of Jining Medical College,Jining 272029,China；2Department of Imaging and Nuclear Medicine,Tianjin Medical University Cancer Institute and Hospital，Tianjin 300060,China;3Department of Nuclear Medicine,Peking Union Medical College Hospital,Beijing 100730,China
Abstract：ObjectiveTo investigate the usefulness of 99Tc-MIBI scintigraphy in diagnosing and predicting therapeutic response of nasal type NK/T-cell lymphoma.MethodsFifty-eight patients with histologically proved primary nasal type NK/T-cell lymphoma were enrolled，and were divided into four groups,as complete remission group,partial remission group,stable disease group(SD),progressive disease group(PD).All patients underwent 99Tc-MIBI SPECT/CT scintigraphy before and after chemoradiothetapy.Tumor-to-background (T/N) ratios were calculated.ResultsThe accuracy of 99Tc-MIBI SPECT-CT was 84.5%.The T/N value of before therapy (3.9±1.9) was higher than that after therapy(1.6±0.7).Before therapy,the T/N value of good responders was significantly higher than that in poor responders (t=4.07，P=0.025).In good responders,the T/N value of before therapy also was higher than that after therapy(t=8.29，P=0.003).The T/N value of patients with several lesions were higher than patients in the other two groups（t=5.15，4.39；P=0.035，0.032）. The T/N value rate was lower than those in the other two groups （t=6.27，4.96；P=0.048，0.033）.The before therapy T/N value of the patients with Nasal lymphoma or Nasopharyngeal lymphoma were also higher than those in after therapy （t=2.97，3.08；P=0.017，0.028）.Conclusion99Tc-MIBI scintigraphy plays a very important role in diagnosing and predicting therapeutic response of primary nasal type NK/T-cell lymphom.
