Abstract：Objective To explore the influence factors associated with cardiovascular risk factors in patients with schizophrenia.Methods 1706 cases of schizophrenia patients (research group) and 81 cases of healthy people (normal group) were retrospectively analyzed,including basic information,body mass index and blood lipid levels.Person correlation analysis was focused on the following aspects:team age,sex,occupation,marriage,smoking,alcohol consumption,progression,electrocardiogram(ECG),brain electrical activity mapping (BEAM),systolic blood pressure (SBP),diastolic blood pressure (DBP),body mass index (BMI),fasting plasma glucose (FBG),triglycerides (TG),cholesterol (TC) and high-density lipoprotein (HDL-C).Results Metabolic cardiovascular risk factors in research team SBP,DBP,BMI,FBG,TG,TC and HDL-C were respectively (114.78±16.77)mmHg，(77.17±21.22)mmHg，(22.34±4.22)kg/m2，(4.43±0.98)mmol/l，(1.62±0.81)mmol/l，(3.88±0.82)mmol/l，(1.21±0.34)mmol/l) and the data of the control group were （114.05±14.11）mmHg，(73.21±8.94)mmHg，(22.66±2.90)kg/m2，(5.38±0.50)mmol/l，(1.49±1.07)mmol/l，(4.16±0.63)mmol/l，(1.41±0.22)mmol/l.IFC,TC and HDL-C data differed with each group,which had statistically significant values (t=53.93,12.49,29.09;P<0.05);and further analysis in different sex groups showed no significant difference (P>0.05);there were significant differences for FBG between different group and different age group (F=38.37,0.27；P<0.05)；he FBG,TC and HDL-C in first-episode tpatients and control group had significant differences (P<0.05);Comparing metabolic cardiovascular factors (SBP,DBP,BMI,FBG,TG,TC and HDL-C) with gender,age,geography,career,marriage,the course of the disease,mode of onset,drinking alcohol,smoking,ECG,BEAM,found positive relationship between BMI and smoking,mode of onset (r=0.082,0.104,P<0.05）；positive relationship between SBP and mode of onset （r=0.082，P<0.05）；positive relationship between DBP and mode of onset,ECG（r=0.049,0.069，P<0.05）;FBG negatively correlated to age,marriage,the course of the disease,smoking (r=-0.056,-0.050，-0.126，-0.054；P<0.05);TG positively correlated to age,marriage (r=0.056,0.055,P<0.05),and negatively related to the geography,smoking (r=-0.053,-0.062,P<0.05);TC negatively related with smoking (r=-0.050,P<0.05);HDL-C negatively related with drinking alcohol (r=-0.051,P<0.05).ConclusionsFBG,TC,HDL-C and other metabolic risk factors in schizophrenia patients are more prominent than those in the general population,and have relationship with area,smoking,drinking alcohol,marriage,course of diseases.Patients′ lifestyle is the important cause of metabolic risk factors.
