Diagnosis and literature review of multicentric castleman disease
Song Min1,Su Na2,Liu Yan2,Jiang Shenghua2,Jiang Luning2
1Graduate School,Jining Medical University，Jining 272067，China;2Department of Respiration,Affiliated Hospital of Jining Medical University，Jining 272029，China
Abstract：ObjectiveTo explore the diagnostic features of multicentric castleman disease(MCD).MethodsThe clinical features of a MCD patient，who was diagnosed in respiratory department of the Affiliated Hospital of Jining Medical University in 2016 were analyzed.Relevant literatures were reviewed and characteristics of clinical diagnosis of MCD were summarized.ResultsA 29 year old woman was hospitalized because of fever,fatigue over ten days.Positron emission tomography computed tomography（PET/CT） showed bilateral neck,clavicle, mediastinal, bilateral axillary, retroperitoneal, abdominal, pelvic, bilateral inguinal nodes enlargement and metabolism were increased in different degrees.Bilateral pleural effusion and atelectasis,pelvic effusion bone metabolism were increased,the features were in accordance with the PET/CT manifestation of CD.MixMCD was diagnosed by cervical lymph node biopsy.Immunohistochemical showed CD3T lymphocytes (+), CD20B lymphocytes (+), CD21 follicular FDC showing reticular (+), the percentage of Ki-67 positive cells was higher than 75%, the percentage of positive cells in the follicular area was 5%～10%, CD34 blood vessels (+).ConclusionThe imaging manifestations of the disease manifests certain characteristics,early biopsyhistopathological examination is helpful for diagnosis.
