300222天津医科大学精神卫生研究所天津市精神卫生中心南开大学附属安定医院1；300070天津医科大学精神卫生学系2；39120Magdeburg,Clinical Affective Neuroimaging Laboratory, Otto von Guericke University, Germany3；3917Tübingen, Department of Psychiatry and Psychotherapy, University of Tübingen, Germany4；325000温州市第七人民医院5
Effect of treatment time on antidepressant effect of ketamine： current research status and future directions
Li Shen1,2, Li Jie1, Tian Hongjun1, Albert Leemon3, Walter Martin4, Zhuo Chuanjun1
1Tianjin Mental Health Research Institute, Tianjin Mental Health Center, Anding Hospital Affiliated to Nankai University, Tianjin 300222, China; 2Department of Psychiatry, Tianjin Medical University, Tianjin 300070, China;3 Clinical Affective Neuroimaging Laboratory, Otto von Guericke University, Magdeburg 39120, Germany; 4Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen 3917, Germany
Abstract：Depressive disorder is a common serious mental illness, with significant disability rate and mortality, which has caused serious burden to society and family. At present, nearly half of the depressive patients are unable to get effective treatment. In clinical practice, ketamine was widely observed to alleviate depressive symptoms effectively. However, its antidepressant mechanism is not clear. Focusing on the progresses in antidepressive mechanism of ketamine, this review summarizes the complex interaction mechanism about acute and delayed effect of ketamine, and puts forward the feasible scheme of design based on the existing literatures and previous researches, which aims to provide scientific basis for clinical application of ketamine as an antidepressant.
李申1,2李洁1田红军1Albert Leemon3Walter Martin4禚传君1,5. 治疗时间对氯胺酮抗抑郁作用影响的研究概况及未来展望[J]. 中华诊断学电子杂志, 2018, 6(3): 151-156.
Li Shen1,2, Li Jie1, Tian Hongjun1, Albert Leemon3, Walter Martin4, Zhuo Chuanjun1. Effect of treatment time on antidepressant effect of ketamine： current research status and future directions. zhzdx, 2018, 6(3): 151-156.
