马晓燕 Frank Larφi 李猛 Walter Martin 林小东 陈策 刘莎 徐勇 禚传君 Steffen Gais
300222天津市精神卫生研究中心天津市安定医院1;4000Lie′ge,Psychology of University of Lie′ge2;72076Tübingen, Psychiatry and Psychotherapy3,Institute of Medical Psychology and Behavioral Neurobiology6, University Tübingen;325000温州第七人民医院精神科4;030001太原,山西医科大学第一医院精神科5
A review and overview of the neuroimaging-genetics features of auditory verbal hallucinations among different mental disorders based on treatment target pattern recognition
Ma Xiaoyan1, Frank Larφi2, Li Meng3, Walter Martin3, Lin Xiaodong4, Chen Ce4, Liu Sha5, Xu Yong5, Zhuo Chuanjun1,Steffen Gais6
1Department of Psychiatry, Tianjin Mental Health Center, Tianjin Anding Hospital, Tianjin 300222, China; 2Department of Psychology, University of Lie′ge, International Consortium on Hallucination Research, ICHR, Lie′ge 4000, Belgium; 3Department of Psychiatry and Psychotherapy, 6Institute of Medical Psychology and Behavioral Neurobiology,University of Tübingen,Tübingen 72076, Germany; 4Department of Psychiatry, Wenzhou Seventh Pepole′s Hospital, Wenzhou 325000, China; 5Department of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan 030001, China
Abstract:Auditory verbal hallucinations (AVHs) are defined as the patients experience of the existence of “real voice” related to themselves when they were in an environment with the absence of external real voice stimulus and they are suffering from these “voice” . AVHs individuals are usually accompanied with higher disability and mortality compared to general populations. AVHs can be observed among variety of mental disorders, which subsequently cause misdiagnosis or mistreatment of diseases. Hence, it has become an urgently scientific issue to explore the pathological features and precise therapeutic targets of AVHs. Using highthroughput sequencing-based genomics technology and brain image-based brain connectome technology, we try to explore the imaging-genetic characteristics of six categories of patients with schizophrenia, bipolar disorder, unipolar depression, borderline personality disorder, and healthy individuals with AVHs symptoms. Based on these characteristics, the early qualitative diagnosis and prediction index system of AVHs of different diseases will be helpful to study the mechanism of AVHs. The future direction should focus on revealing the common and specific imaging-genetics features in different diseases from three perspectives:endogenous-genetic, endo-phenotypice (neural-circuit/brain network)-phenotypic characteristics (clinical symptoms). This can help us to explore the precise therapeutic targets of AVHs for different diseases and establish early diagnosis and treatment prediction model. These early prediction model can provide objective information to help the clinicians make precise treatment strategies for different diseases, thereby improving treatment outcomes of these dieseses.
马晓燕 Frank Larφi 李猛 Walter Martin 林小东 陈策 刘莎 徐勇 禚传君 Steffen Gais. 多病种言语性幻听症状影像遗传学特征及治疗靶点模式识别的研究概况[J]. 中华诊断学电子杂志, 2019, 7(2): 73-77.
Ma Xiaoyan1, Frank Larφi2, Li Meng3, Walter Martin3, Lin Xiaodong4, Chen Ce4, Liu Sha5, Xu Yong5, Zhuo Chuanjun1,Steffen Gais6. A review and overview of the neuroimaging-genetics features of auditory verbal hallucinations among different mental disorders based on treatment target pattern recognition. zhzdx, 2019, 7(2): 73-77.