Research situation on the role of glycogen synthase kinase-3β in the pathogenesis and treatment of Alzheimer′s disease
Zhang Mengyang1, Wang Yue2
1Clinical College, Capital Medical University, Beijing 100069, China； 2Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China
Abstract：Alzheimer disease (AD) is the most common age-related senile dementia. Senile plaques and neurofibrillary tangles are two histopathological hallmarks of this disease. Glycogen synthase kinase-3β(GSK-3β) is a key enzyme in glycogen synthesis. The dysregulation of this kinase contributes to many disorders in neurophysiology, especially the formation of senile plaques and neurofibrillary tangles. In this review, we conclude the effects of GSK-3β on the development of AD and the current studies of GSK-3β inhibitors in the treatment of AD.
张梦阳 王玥. 糖原合酶激酶-3β在阿尔茨海默病发病机制及治疗中作用的研究概况[J]. 中华诊断学电子杂志, 2019, 7(2): 98-102.
Zhang Mengyang1, Wang Yue2. Research situation on the role of glycogen synthase kinase-3β in the pathogenesis and treatment of Alzheimer′s disease. zhzdx, 2019, 7(2): 98-102.
