The value of Galectin-3 protein in the diagnosis of human bladder transitional cell carcinoma
Chen Qiang1, Zuo Bingjie2, Liu Yan1, Su Lei1, Sun Guohua1
1Department of Urology, the First People′s Hospital of Ningyang County, Ningyang 271400,China; 2Department of Cardiovascular Medicine, Manzhuang Town Health Center, Manzhuang 271024， China
Abstract：ObjectiveTo investigate the value of Galectin-3 in the diagnosis of human bladder transitional cell carcinoma （TCC）. MethodsGalectin-3 was detected by immunohistochemistry in bladder TCC patients (n=84) who underwent transurethral resection from urology department, the First People′s Hospital of Ningyang County from January 2015 to January 2018. To analyze and compare the expression of Galectin-3 in bladder TCC and its role in pathological grading, clinical staging, initial occurrence and recurrence. ResultsThe positive expression rate of Galectin-3 protein in bladder TCC was 66.67%(56/84), which was significantly higher than that in adjacent tissues （7.69%，4/52） (χ2=17.65, P＜0.01). The expression rates of Galectin.3 protein in poorly differentiated TCC of bladder (grade G2： 68.75%, 22/32, grade G3： 94.12%,16/17) were significantly higher than that in well differentiated TCC of bladder (grade G1:42.86%,15/35) (χ2=2.39, P＜0.05). The positive expression rate of Galectin-3 protein increased with the increase of clinical stage and reached 100%(12/12) (χ2=10.44, P＜0.01) when the clinical stage was T3. The expression of Galectin-3 protein in recurrent bladder TCC (69.23%,18/26) was higher than that in primary bladder TCC, but there was no significant difference (62.07%, 36/58) (χ2=0.35, P＞0.05). Conclusion Galectin.3 can be used as a biomarker for the diagnosis and severity assessment of bladder TCC.
陈强 左丙杰 刘岩 苏雷 孙国华. Galectin-3蛋白在人膀胱移行细胞癌诊断中的应用价值[J]. 中华诊断学电子杂志, 2020, 8(2): 117-120.
Chen Qiang1, Zuo Bingjie2, Liu Yan1, Su Lei1, Sun Guohua1. The value of Galectin-3 protein in the diagnosis of human bladder transitional cell carcinoma. zhzdx, 2020, 8(2): 117-120.
