Analysis of digestive system damage and mental health features of patients with Corona Virus Disease 2019 in Guangzhou
You Leqing1, Hu Zhongwei1, Jia Lin2, Chen Zhiqian1, Shen Aiping3
1Department of Gastroenterology, 3Department of the Second Infection, Guangzhou Eighth People′s Hospital Affiliated to Guangzhou Medical University, Guangzhou 510060, China; 2Department of Gastroenterology, Nansha Hospital, Guangzhou First People′s Hospital, Guangzhou 511457, China
Abstract：ObjectivesTo explore the digestive system damage and mental health features of patients with Corona Virus Disease 2019 (COVID-19) in Guangzhou. MethodsThe clinical data of 123 patients with confirmed COVID-19 in Guangzhou Eighth People′s Hospital from January 25, 2020 to February 20, 2020 were collected, and 85 healthy controls were selected at the same time. The differences of digestive tract symptoms and the characteristics of liver injury among common （n=87） and severe and critical patients （n=36）were compared. The time-effect relationship of digestive tract damage was evaluated, and the main symptoms were analyzed by multivariate analysis. The Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA) and Pittsburgh Sleep Quality Index (PSQI) were evaluated and compared between some patients (85 cases) and healthy control group (85 cases). ResultsAmong the general symptoms, fever and cough were the most common symptoms ［112 patients (91.06%) and 94 patients (76.42%), respectively］.In terms of accompany digestive tract symptoms, anorexia was the most common symptom (55 patients, 44.72%), followed by diarrhea (23 patients, 18.70%). A total of 2 patients (1.63%) with the first clinical manifestation of digestive system symptoms. Among severe and critical patients, the numbers of patients with anorexia ［28 patients（77.78%）］ and abdominal pain ［5 patients（13.89%)］ were more than those in the common group ［27 patients (31.03%), 2 patients (2.30%)］, the differences were statistically significant (all P＜0.05). The symptoms of diarrhea were significantly relieved 1-4 days later,（2.69±0.87）days on average, while the anorexia lasted for 5-15 days, with an average of (9.67±2.54) days. Alanine aminotransferase (ALT) ［36.60（19.57, 57.50）］ and aspartate aminotransferase (AST) ［39.70（22.40, 61.75）］ levels of severe and critical patients were significantly higher than those of common group ［20.50（12.70, 27.88）,18.80 （13.40, 22.90）］（Z=-3.91，-5.36，all P＜0.05）, while albumin (ALB) level was significantly lower than that of common group ［33.35（30.02, 35.30）, 38.10（34.90, 39.90）］ （Z=-5.61,P＜0.05）. Logistic regression analysis showed that oxygenation index (OR=0.99, 95%CI:0.98-0.99), anxiety or depression (OR=0.18, 95%CI:0.03-0.97) had significant influence on anorexia (all P＜0.05). The incidences of anxiety ［28(32.94%)］, depression ［29(34.12%)］ and sleep disorder ［40(47.06%)］ in patients infected by COVID-19 were significantly higher than those in healthy control group ［9(10.59%), 8(9.41%), 10(11.76%)］, the differences were significant （χ2=12.47, 15.23, 25.50, all P＜0.05）. ConclusionsAnorexia was the most common digestive tract symptom in COVID-19 patients. Some COVID-19 patients may be accompanied by anxiety, depression or sleep disorders, and oxygenation index, anxiety or depression are important influencing factors of anorexia.
游乐卿 胡中伟 贾林 陈志乾 沈爱萍. 广州市新型冠状病毒肺炎患者消化系统损害及心理健康特征分析[J]. 中华诊断学电子杂志, 2020, 8(3): 191-197.
You Leqing1, Hu Zhongwei1, Jia Lin2, Chen Zhiqian1, Shen Aiping3. Analysis of digestive system damage and mental health features of patients with Corona Virus Disease 2019 in Guangzhou. zhzdx, 2020, 8(3): 191-197.
