Abstract：ObjectiveTo explore the relationship of P53 gene and the prognosis of radical resection of newonset esophageal squamous cell carcinoma (ESCC). MethodsAll the related literatures from 7 databases of Web of Science, Embase, Pubmed, Cochrane Library, CNKI, VIP and Wanfang were searched by April 30, 2020. Fixed effect model was used to calculate combined hazard ratio (HR) and its 95%CI. Egger′s test was used to analyze the publishing bias. ResultsA total of 29 highquality articles (NOS≥5 points) from Japan (16 articles), China (10 articles), Brazil (1 article), Iran (1 article) and Germany (1 article) were included in this metaanalysis, covering 4652 ESCC patients. The P53 gene was related to the overall survival during follow-up after radical resection of ESCC, and the combined effect was HR=1.12(95%CI:1.01-1.22). Furthermore, the combined effect of P53 positive expression was HR=1.07（95%CI:0.93-1.20）, the overall effect value of positive expression of P53 (nuclear staining≥10%) was HR=1.23 (95%CI:1.03-1.42) and positive expression of P53 (nuclear staining＞50%） was HR=1.15 (95%CI:0.77-1.53), the combined effect of P53 high expression was HR=1.20 (95%CI:1.01-1.39), the combined effect of P53 over-expression was HR=1.57（95%CI:1.09-2.06）and the combined effect of P53 mutation was HR=1.56 (95%CI: 0.06-3.06). ConclusionsHigh and positive expression of P53 gene (nuclear staining≥10%) and overexpression may be associated with poor prognosis in patients undergoing radical resection of ESCC, which may provide reference value for clinical prognosis. However, the clinical prognostic significance of mutation of P53 gene need further researches.
郝凤成 李国良 王亚洲 刘德彪 周旋 刘燕. P53基因与食管鳞癌根治术预后的循证分析[J]. 中华诊断学电子杂志, 2020, 8(3): 208-216.
Hao Fengcheng1, Li Guoliang2, Wang Yazhou2, Liu Debiao2, Zhou Xuan2, Liu Yan2. An evidence-based analysis of P53 and the prognosis of radical resection of esophageal squamous cell carcinoma. zhzdx, 2020, 8(3): 208-216.
