The predictive value of semi-quantitative parameters of dynamic contrast enhanced magnetic resonance imaging with human epidermal growth factor receptor 2 in breast cancer
Meng You1, Zhang Fan2, Liu Chenlu2, Shen Yuying2, Cai Qing2, Chen Shuangqing2
1Department of Breast Surgery, 2Department of Radiology, Suzhou Hospital Affiliated to Nanjing Medical University, Suzhou 215001, China
Abstract：ObjectiveTo investigate the predictive value of semi-quantitative parameters of dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) with human epidermal growth factor receptor 2 (Her-2) in breast cancer. MethodsFrom January 2016 to December 2019, a total of 65 patients with invasive breast cancer who underwent DCE-MRI in the Imaging Department of Suzhou Hospital Affiliated to Nanjing Medical University and confirmed by pathology were selected. Her-2 expression was detected in all patients by immunohistochemical method, and the patients were divided into Her-2 positive group and Her-2 negative group. Semiquantitative parameters including rate of contrast enhancement for contrast agent inflow (Win), rate of contrast decay for contrast agent outflow (W-out), timeto-peak enhancement after contrast agent injection (TTP), positive enhancement integral (PEI) and time-signal intensity curve (TIC) were compared between the two groups. Further, receiver operating characteristic (ROC) curve was used to analyze the effectiveness of each parameter in the diagnosis of positive Her-2. ResultsAmong the 65 cases, immunohistochemical staining showed Her-2 positive in 31 cases and Her-2 negative in 34 cases. Compared with Her-2 negative group ［1.49±0.21, (0.71±0.12)min］, the values of W-in (1.25±0.19) and TTP ［(0.55±0.10)min］ in the Her-2 positive group were significant decreased (t=-4.99, -5.46, all P＜0.01), while the value of W-out (0.28±0.77) in the Her-2 positive group was significant increased compared to Her-2 negative group (0.20±0.08) (t=4.54, P＜0.01). However, there was no significant difference in PEI values (145.12±15.81,141.54±17.69) between the two groups (t=0.85, P＞0.05). In addition, TIC types of the two groups were mainly type Ⅱ (11 cases, 15 cases) or Ⅲ (17 cases, 16 cases), and there was no significant difference (χ2=0.42，P＞0.05). The area under the curve (AUC) of semi-quantitative parameters combination of DCE-MRI (AUC=0.890) was significant higher than that of single W-in, W-out, TTP, PEI（AUC=0.813, 0.802, 0.829, 0.589） respectively, and the differences of AUC were statistically significant (Z=3.39, 5.24, 3.08, 7.34,all P＜0.05). ConclusionSemi-quantitative parameters of DCE-MRI have a certain clinical value in the determination of breast cancer with Her-2 positive, and they can provide a reference for clinical treatment.
孟优 张帆 刘晨鹭 沈玉英 蔡庆 陈双庆. 动态增强磁共振半定量参数对乳腺癌人表皮生长因子受体-2表达的预测价值[J]. 中华诊断学电子杂志, 2021, 9(1): 40-45.
Meng You1, Zhang Fan2, Liu Chenlu2, Shen Yuying2, Cai Qing2, Chen Shuangqing2. The predictive value of semi-quantitative parameters of dynamic contrast enhanced magnetic resonance imaging with human epidermal growth factor receptor 2 in breast cancer. zhzdx, 2021, 9(1): 40-45.
