Application and challenge of polygenic risk score in prevention and prediction of schizophrenia
Li Qiaojun1, Lyu Xingping2, Xu Jiayuan3, Zhuo Chuanjun4
1School of Information Engineering, 2School of Science, Tianjin University of Commerce, Tianjin 300134, China; 3Department of Radiology, Tianjin Medical University General Hospital, Tianjin 300052, China; 4Key Laboratory of Realtime Brain Circuits, Tianjin Fourth Center Hospital, Tianjin 300140, China
Abstract：Schizophrenia is a complex disease with high heritability. Many susceptibility loci have been found in candidate genes and genomewide association studies. Recently, polygenic risk score (PRS) has been playing an important role in the diagnosis, discrimination, and prediction of schizophrenia. Also, PRS could provide important assistance for the early prevention and treatment of potential schizophrenics in the future. This article discusses the application and challenges of PRS in the prevention and prediction of schizophrenia.
