Research progress of extracellular vesicles in the diagnosis and pathogenesis of Barrett esophagus and esophageal adenocarcinoma
Wang Junli1, Zhang Wenping2
1Graduate School, Changzhi Medical College, Changzhi 046000,China; 2Department of Cardiothoracic Surgery, Heping Hospital Affiliated to Changzhi Medical College, Changzhi 046000, China
Abstract：In recent years, the incidence of esophageal adenocarcinoma (EAC) is increasing in China, and Barrett esophagus (BE) is the highest risk group for EAC. The main clinical symptom of EAC is progressive dysphagia, the early symptoms are not obvious, and the disease has progressed to advanced stage when most patients are found and diagnosed. Therefore, the prognosis of EAC is generally poor, and early screening, prevention and treatment are still essential. Extracellular vesicles (EVs) are rich in proteins, nucleic acids, lipids and other substances derived from parental cells. EVs can be used in the early diagnosis of diseases since the contents of EVs have been shown to provide useful insights into cellular transformation and prooncogenic processes. This paper reviews current research reports on EVs as a diagnostic biomarker, and summarizes its role in the progression of BE and EAC, in order to provide some help for experimental research and clinical practice of these diseases.
王军丽 张文平. 细胞外囊泡在Barrett食管及食管腺癌诊断和发病中的研究进展[J]. 中华诊断学电子杂志, 2021, 9(3): 207-210.
Wang Junli1, Zhang Wenping2. Research progress of extracellular vesicles in the diagnosis and pathogenesis of Barrett esophagus and esophageal adenocarcinoma. zhzdx, 2021, 9(3): 207-210.
