Abstract：ObjectiveTo explore the diagnostic features of recurrent acute disseminated encephalomyelitis (ADEM) in adults. MethodsThe clinical data of an adult patient with recurrent ADEM in Neurology Department of Taian Municipal Hospital from May 2018 to May 2020 were retrospectively analyzed. The diagnostic features of ADEM were summarized and relevant literatures were reviewed. ResultsThe patient had a history of infection before the onset of 3 episodes, and had dizziness, slurred speech, and unsteady walking in each episode. Blood and cerebrospinal fluid oligoclonal zone(-). Blood and cerebrospinal fluid aquaporin 4 (AQP4) antibody(-), myelin basic protein (MBP) antibody(-), myelin oligodendrocyte glycoprotein (MOG) antibody(-) and ganglioside profile antibody(-). MRI of the brain did not exclude changes in demyelination. There was no obvious enhancement in brain MRI enhancement. MRI arterial spin labeling (ASL) perfusion imaging suggested that the brain was hypoperfused, and demyelinating disease was considered. Magnetic resonance spectroscopy (MRS) conformed to the MRS manifestations of demyelinating lesions. Symptoms improved after hormone shock therapy for 3 episodes. ConclusionThe clinical manifestations of ADEM are complex and varied, which can be correctly diagnosed by means of serum antibody, imaging and neuroelectrophysiology.
王雪 赵名娟 方永莉. 成人复发型急性播散性脑脊髓炎的诊断学特征并文献复习[J]. 中华诊断学电子杂志, 2022, 10(1): 21-25.
Wang Xue, Zhao Mingjuan, Fang Yongli. Diagnostic features of recurrent acute disseminated encephalomyelitis in adults and literature review. zhzdx, 2022, 10(1): 21-25.
