The research progress of pathogenesis of focal cortical dysplasia
Xu Jie1, Li Qiubo2, Kong Qingxia2, Zheng Mingxue1
1Clinical Medical College, Jining Medical University, Jining 272013, China; 2Department of Neurology, Affiliated Hospital of Jining Medical University, Jining 272029, China
Abstract：Focal cortical dysplasia (FCD) is a malformation of cortical development highly associated with drug-refractory epilepsy. It is one of the main causes of refractory epilepsy. In the past 20 years, the relationship between FCD and drug-refractory epilepsy has been recognized. According to the classification of the International League Against Epilepsy, FCD can be divided into FCD Ⅰ (a, b, c), FCD Ⅱ (a, b) and FCD Ⅲ (a, b, c). In recent years, the pathogenesis of FCD has been proposed. The activation of PI3K-AKT-mTOR signal pathway, the effect of GATOR on mTOR, TSC gene mutation, PTKs signal pathway gene mutation, GABA receptor hypothesis, TRPC activation, inflammation and so on can lead to FCD which can cause epilepsy. The authors summarize the previous studies on the pathogenesis of FCD and explore the mechanism of refractory epilepsy caused by FCD, so as to seek new therapeutic drugs and improve the prognosis of patients with FCD.
许洁1李秋波2孔庆霞2郑明雪1. 局灶性皮层发育不良发病机制研究进展[J]. 中华诊断学电子杂志, 2022, 10(1): 31-35.
Xu Jie1, Li Qiubo2, Kong Qingxia2, Zheng Mingxue1. The research progress of pathogenesis of focal cortical dysplasia. zhzdx, 2022, 10(1): 31-35.
