The predictive value of plasma homocysteine for coronary artery disease in female patients with hypertension
Lin Yao, Huang Xiaoling, He Zhaoxia, Mou Boyong, Mou Yan
Department of Cardiovascular Medicine, Wenjiang District People′s Hospital of Chengdu (Sichuan Provincial People′s Hospital Wenjiang Hospital), Chengdu 611130, China
Abstract：ObjectiveTo explore the predictive value of plasma homocysteine (Hcy) for coronary artery disease (CAD) in female hypertensive patients. MethodsFrom June 2018 to September 2020, 231 female patients with essential hypertension who underwent CAD in Wenjiang District People′s Hospital of Chengdu were selected. The laboratory indicators at the time of admission were collected, and the patients were divided into the normal coronary artery group (n=163) and the CAD group (n=68) according to the CAD SYNTAX score. The above indicators of the two groups of patients were compared, the influence of each indicator on CAD was analyzed by the multivariate logistic regression analysis method, and the predictive value of each indicator on CAD was judged by receiver operating characteristic (ROC) curve. ResultsAmong the indicators, the differences age ［(65.82±5.88)years, (62.09±4.92)years］, leukocyte count ［(6.82±1.54)×109/L, (5.73±1.09)×109/L］, neutrophil count ［(4.71±1.29)×109/L, (3.88±0.84)×109/L］, low-density lipoprotein cholesterol level ［（3.24±0.42）mmol/L，（2.75±0.51）mmol/L］ and homocysteine level ［(32.05±6.83)μmol/L, (14.27±3.84)μmol/L］ between the CAD group and the normal group were statistically significant (t=4.95, 6.10, 5.79, 6.99, 25.10, all P＜0.01).
The multivariate logistic regression analysis results on a single factor basis showed that elevated levels of low-density lipoprotein cholesterol ［OR=1.449, 95%CI (1.016-2.066)］ and Hcy ［OR=1.493, 95%CI (1.064-2.096)］ were risk factors for CAD in female hypertensive patients (all P＜0.05). ROC curve analysis results showed that the cut-off values of lowdensity lipoprotein cholesterol and Hcy for predicting CAD were 2.96mmol/L and 25.03μmol/L, respectively,and area under curve (AUC) were 0.650, 0.796. The AUC of the two indicators combined diagnosis was 0.879, and its diagnostic efficiency was higher than that of each indicator alone (Z=4.26, 4.72, all P＜0.05). ConclusionsElevated levels of low-density lipoprotein cholesterol and Hcy are risk factors for CAD in female hypertensive patients. The combined detection of the two indicators can effectively improve the predictive effect of CAD.
蔺曜 黄晓玲 何昭霞 牟博勇 牟燕. 血浆同型半胱氨酸水平对女性高血压患者冠状动脉病变的预测价值[J]. 中华诊断学电子杂志, 2022, 10(1): 48-52.
Lin Yao, Huang Xiaoling, He Zhaoxia, Mou Boyong, Mou Yan. The predictive value of plasma homocysteine for coronary artery disease in female patients with hypertension. zhzdx, 2022, 10(1): 48-52.
