Diagnostic features of idiopathic multicentric Castleman disease and literature review
Du Pengyu1, Zhu Honghong2, Sun Bing3, Ran Qiyu1, Kong Lei1
1Clinical Medical College, 3College of Integrated Traditional Chinese and Western Medicine, Jining Medical University, Jining 272013, China； 2Department of Emergency, Affiliated Hospital of Jining Medical University, Jining 272029, China
Abstract：ObjectiveTo explore the diagnostic features of idiopathic multicentric Castleman disease. MethodsThe clinical data of a patient with idiopathic multicentric Castleman disease admitted to the emergency department of the Affiliated Hospital of Jining Medical University on June 26, 2020 was retrospectively analyzed, and relevant literatures were reviewed. ResultsThe patient was a 31-year-old young female who was admitted to the hospital for "fever for 1 week", accompanied by fatigue, cough, and abdominal distension. Physical examination showed multiple lymph node enlargement, low breath sounds in both lower lungs, and dull percussion note. Chest CT showed a large amount of pleural effusion, and anti-infective treatment was not effective.Human herpesvirus-8 (HHV-8) DNA quantitative detection was in the normal range, and human immunodeficiency virus (HIV) negative. The pathological examination of the left cervical lymph node biopsy showed reactive hyperplasia of lymphatic tissue, and the morphology showed the hyaline vascular change of Castleman′s disease. The patient was diagnosed with idiopathic polycentric Castleman′s disease. ConclusionEarly improvement of HHV-8 DNA quantitative detection, immunological indicators, bone marrow biopsy and lymph node pathological examination are helpful for early diagnosis and typing of Castleman′s disease.
杜鹏宇1朱红红2孙冰3冉启玉1孔蕾1. 特发性多中心型Castleman病的诊断学特征并文献复习[J]. 中华诊断学电子杂志, 2022, 10(1): 63-66.
Du Pengyu1, Zhu Honghong2, Sun Bing3, Ran Qiyu1, Kong Lei1. Diagnostic features of idiopathic multicentric Castleman disease and literature review. zhzdx, 2022, 10(1): 63-66.
