Correlation between glycosylated hemoglobin and testosterone in non-obese male patients with type 2 diabetes mellitus
Wang Yaru1, Liu Fang1, Chen Zonglan2, Zhang Mei2, Ban Bo2
1College of Clinical Medicine, Jining Medical University, Jining 272013, China; 2Department of Endocrinology, Affiliated Hospital of Jining Medical University, Jining 272029, China
Abstract：ObjectiveTo investigate the correlation between glycosylated hemoglobin (HbA1c）and serum total testosterone (TT) level in nonobese male patients with type 2 diabetes mellitus (T2DM). MethodsA total of 387 non-obese male T2DM patients hospitalized in the Endocrinology Department, Affiliated Hospital of Jining Medical University from November 2019 to April 2021 were selected. Their baseline clinical data were collected and grouped according to the quartile of HbA1c level to compare the differences of TT levels among the four groups. The link between HbA1c and TT level was investigated using Pearson correlation analysis and multiple linear regression. ResultsThe TT level was 3.97 (3.06, 4.98)ng/mL in non-obese male T2DM patients, with testosterone insufficiency (＜3.5ng/mL) accounting for 36.43%（141/387）. According to the quartile of HbA1c level, TT levels decreased as HbA1c levels increased, and the difference was statistically significant (F=2.99, P＜0.05). Pearson correlation analysis showed that TT was negatively correlated with HbA1c (r=-0.13), waist circumference (r=-0.14), WHT (r=-0.12), TG (r=-0.16), fasting C-peptide (r=-0.24), and positively correlated with HDL-C (r=0.19) (all P＜0.05). Multiple linear regression analysis included TT and HbA1c, age, waist circumference, WHT, HDLC, TG, and fasting C-peptide. In non-obese male T2DM patients, HbA1c was found to be significantly adversely linked with TT (B=-0.18, P＜0.01). ConclusionIn non-obese male T2DM patients, HbA1c is inversely linked with TT level.
王雅儒 刘芳 陈宗兰 张梅 班博. 男性非肥胖2型糖尿病患者糖化血红蛋白与睾酮水平的相关性[J]. 中华诊断学电子杂志, 2022, 10(2): 99-103.
Wang Yaru1, Liu Fang1, Chen Zonglan2, Zhang Mei2, Ban Bo2. Correlation between glycosylated hemoglobin and testosterone in non-obese male patients with type 2 diabetes mellitus. zhzdx, 2022, 10(2): 99-103.
