The prediction of serum vitamin D level on lower limb strength reduction in maintenance hemodialysis patients
Li Lei1, Liu Juan2, Lu Yue3
1Department of Outpatient, Chaoyang Second Retreat for Retired Cadres in Beijing Garrison Area, Beijing 100013, China; 2Department of Outpatient, Chaoyang Eleventh Retreat for Retired Cadres in Beijing Garrison Area, Beijing 100101, China; 3School of Nursing, Peking University, Beijing 100191, China
Abstract：ObjectiveTo explore the predictive efficacy of serum vitamin D level on lower limb strength loss in patients undergoing maintenance hemodialysis (MHD). MethodsThis is a cross-sectional study with convenient sampling. In 95 MHD patients who were selected from Blood Purification Center, Strategic Support Force Medicial Center from September 2018 to October 2018, serum 25(OH)D3 level and a 5-repetition sitto-stand test (5STS) were used to represent serum vitamin D level and lower limb strength. MHD patients were divided into two groups based on the completion time of the 5-STS: normal muscle strength (n=85) and decreased muscle strength (n=10), and the demographic characteristics and laboratory indicators of the two groups were compared. The influencing factors of lower extremity muscle weakness were studied using multivariate logistic regression, and a receiver operating characteristic (ROC) curve was drawn to assess the specificity and sensitivity of the above factors in predicting lower extremity muscle weakness in MHD patients. ResultsSerum 25(OH)D3 levels ranged from 11.00nmol/L to 99.50nmol/L, with 31.23（19.90-43.30）nmol/L as the median, and the time to complete 5-STS ranged from 3.55 sec to 18.71 sec, with 9.81（7.12，12.43） sec as the median. Lower limb strength decreased in 10 cases (10.53%). Multivariate logistic regression revealed that serum 25(OH)D3 was a protective factor for lower limb weakness in MHD patients［OR=0.761, 95%CI(0.592-0.978), P=0.033］. ROC analysis revealed that the AUC of 25(OH)D3 was 0.815, with sensitivity and specificity of 80.00% and 8000%, respectively. ConclusionThe level of serum 25(OH)D3 is low in MHD patients especially in those with reduction of strength in lower limbs. The 25(OH)D3 can predict the reduction of strength in lower limb of MHD patients with a satisfying sensitivity and specificity.
李蕾 柳娟 陆悦. 血清维生素D水平对维持性血液透析患者下肢肌力减退的预测作用[J]. 中华诊断学电子杂志, 2022, 10(3): 197-201.
Li Lei1, Liu Juan2, Lu Yue3. The prediction of serum vitamin D level on lower limb strength reduction in maintenance hemodialysis patients. zhzdx, 2022, 10(3): 197-201.
