Abstract：ObjectiveTo investigate the pathogenic characteristics and pathogenic spectrum changes of sputum culture in hospitalized children with bronchopneumonia before and after the COVID-19 epidemic in northern Chongqing. MethodsA total of 4872 children with bronchopneumonia aged from 29 days to 14 years old(excluding 14 years old) admitted to the Pediatrics Department of Chongqing Ninth People′s Hospital from January 24, 2018 to January 23, 2022 were included, and the sputum culture samples were analyzed for the first time after hospitalization. Taking the data when the COVID-19 epidemic control to the first-level response in chongqing as the critical point, the data from January 24, 2018, to January 23, 2020 (pre-COVID-19) epidemic and the data from January 24, 2020, to January 23, 2022 (post-COVID-19) epidemic were used for age and gender comparison. Data from February 5, 2019 to February 11, 2021 were used to compare the pathogenic detection of sputum culture in different seasons before and after the epidemic. ResultsThere were 1597 cases (32.78%) with positive sputum culture (≥1 pathogen was detected), of which Streptococcus pneumoniae accounted for the highest proportion (468/1597, 29.30%), followed by Haemophilus influenzae (294/1597, 18.41%), and 21 cases (1.31%） of mixed infection (≥ 2 pathogens were detected). Among the pathogens detected, gram-negative bacteria (833/1597, 52.16%) accounted for a higher proportion than gram-positive bacteria (743/1597, 46.52%). The detection rates of pathogens before and after the epidemic were 35.54% (1065/2997), 28.37% (532/1875), respectively. In male and female children groups, 29 days to 6 months age group, and 1-3 years old age group, the detection rates of pathogens before the epidemic were higher than those after the epidemic, and the differences were statistically significant (all P＜0.05). The detection rates of Haemophilus influenzae, Staphylococcus aureus and Escherichia coli before the epidemic were higher than those after the epidemic, and the result was consistent in different sex groups (all P＜0.05). Among male children, the detection rate of Streptococcus pneumoniae before the epidemic was higher than that after the epidemic(P＜0.05). The detection rate of pathogens gradually decreased in spring, summer, autumn and winter before the epidemic, and the highest detection rate of pathogens was in the winter after the epidemic. There were significant differences in the detection rates of Streptococcus pneumoniae and Haemophilus influenzae before and after the epidemic in different seasons. The pathogen detection rate (337/832, 40.50%) in the 29 days to 6 months group was higher than the overall detection rate, and with the increase of age, the overall detection rate and the detection rate of Staphylococcus aureus gradually decreased. Except for the 29 days to 6 months age group, the proportion of Streptococcus pneumoniae was the highest in all other groups. ConclusionsAfter the COVID-19 epidemic, the order of pathogen spectrum of bronchopneumonia sputum culture in children has changed somewhat, but Streptococcus pneumoniae and Haemophilus influenzae are still dominant. After the epidemic, the detection rates of Haemophilus influenzae, Staphylococcus aureus, and Escherichia coli decrease significantly compared with before the epidemic.
刘敏 彭才静 王金能. 重庆市新型冠状病毒肺炎疫情前后儿童支气管肺炎痰培养结果分析[J]. 中华诊断学电子杂志, 2023, 11(2): 97-103.
Liu Min, Peng Caijing, Wang Jinneng. Analysis of sputum culture results of children with bronchopneumonia before and after COVID-19 epidemic in Chongqing. zhzdx, 2023, 11(2): 97-103.
