腰椎间盘退变的生物代谢特征及评价技术研究进展

doi:10.3877/cma.j.issn.2095-655X.2024.03.012

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摘要腰椎间盘退变（LDD）是一类慢性、复杂、多因素导致的骨肌疾病，核心病变是椎间盘结构损伤，逐渐导致其机械稳定性和减震功能丧失，引起顽固性腰腿痛。LDD患者早期缺乏典型临床表现，诊断不易确立，一旦后期结构发生不可逆损伤，临床修复手段和疗效均有限。因此，对其早期识别与提前干预极为关键。鉴于LDD在临床前期即已发生代谢紊乱，这是一个长期、动态且可被调控的量变过程，因此，通过早期监测并干预代谢失衡，可望为LDD的防治开辟新路径。在此背景下，临床亟须发展出一套能够无创、定量、准确且可靠的检测技术，以便及时捕捉LDD早期的生物代谢异常。为此，笔者总结并探讨LDD生物代谢特征的最新研究进展，包括敏感代谢标志物的识别、先进检测技术的应用以及可靠评价指标的建立，旨在为LDD的临床前期预防、干预策略制定及其发病机制的深入研究提供有力支持。

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关键词 ：腰椎间盘退变, 代谢, 早期诊断, 诊断技术和方法, 磁共振成像

Abstract：Lumbar disc degeneration (LDD) is a chronic, complex, and multifactorial musculoskeletal disease. Its core lesion lies in structural damage to the intervertebral disc, which gradually compromises its mechanical stability and shock-absorbing capabilities, resulting in intractable lumbocrural pain. LDD patients often lack typical clinical manifestations in the early stages, posing challenges for accurate diagnosis. Once irreversible structural damage occurs in the later stages, clinical repair options and therapeutic effects are limited. Therefore, early identification and intervention are crucial. Given that metabolic disorders occur even in the preclinical stage of LDD, it is a long-term, dynamic, and controllable quantitative change process, early monitoring and intervention targeting metabolic imbalances could potentially pave the way for novel prevention and treatment strategies for LDD. Against this backdrop, there is an urgent clinical need to develop a non-invasive, quantitative, accurate, and reliable detection technology to promptly capture early biometabolic abnormalities of LDD. This paper summarizes and explores the latest research advancements in understanding the biometabolic characteristics of LDD, including the identification of sensitive metabolic biomarkers, the application of advanced detection technologies, and the establishment of reliable evaluation indicators. The ultimate goal is to provide robust support for preclinical prevention efforts, intervention strategy development, and in-depth investigation into the underlying pathogenesis of LDD.

Key words： Lumbar disc degeneration Metabolism Early Diagnosis Diagnostic techniques and procedures Magnetic resonance imaging

基金资助:福建省区域发展项目（2019Y3007）

通讯作者: 欧阳林， Email: ddcqzg@126.com

引用本文:

欧阳川朱巧珍欧阳林. 腰椎间盘退变的生物代谢特征及评价技术研究进展[J]. 中华诊断学电子杂志, 2024, 12(3): 206-211.
Ouyang Chuan1, Zhu Qiaozhen2,Ouyang Lin2. Research progress on biometabolic characteristics and evaluation techniques for intervertebral disc degeneration. zhzdx, 2024, 12(3): 206-211.

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