Abstract：ObjectiveTo investigate the clinical diagnostics features of wegener granulomatosis.MethodsThe clinical,ultrasonographic,serum biochemical and computed tomography(CT) data of wegener granulomatosis (WG) confirmed by surgery and pathology was retrospectwely analyzed,and relevant literature were reviewed.ResultsCT examination showed there were multiple nodules and cavitations of lung,the boundary was clear,and the diameter of the mediastinal lymph node shadow was about 0.5cm～1.0cm.Laboratory tests showed line anti-M2 mitochondrial antibodies were positive,ultra-sensitivity C-reactive protein was 9.54mg/L,erythrocyte sedimentation rate was 18mm/H,antinuclear antibody was negative,various tumor marker detected by protein chip were normal;tuberculosis test was negative;fungi D glucan was negative;cANCA,pANCA,MPO,PR3,GBM were negative.The direct version of lesions during operation showed a number of different sizes nodules in right upper lobe and the largest diameter was about 1cm.Section surface of the nodule was gray.The microscopic version of lesions showed the lung tissue vascular endothelial was proliferated,wall was thickening,eosinophil infiltration with histiocyte reaction around.ConclusionsWG is a rare granulomatous necrotizing vasculitis involving upper and lower respiratory tracts and the kidneys.Timely diagnosis is the key to the treatment.WG can be diagnosed with endoscopic biopsy in case of unclear radiological and laboratory diagnosis.
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