Significance of the expression of human papilloma virus proto-oncogene proteins E6E7 in non-small-cell lung cancer in Hakka region
Zheng Zhongwen,Wu Jian,Yang Huiling
Department of Respiratory Medicine,Guang Dong General Hospital,Guangzhou
Department of Pathophysiology Teaching and Research Section,Zhongshan School of Medical,Guangzhou
Abstract：ObjectiveTo investigate the clinical and pathological features of non-small-cell lung cancer(NSCLC) infected by human papillomavirus in Hakka region.MethodsSABC immunohistochemical method was used to detect the expression of HPV E6，E7 in forty-three cases with NSCLC and in twenty-seven benign lung specimens,respectively.The expression of the HPV E6,E7 in NSCLC and benign patients was analyzed by Fisher′s exact test and chi-square test.ResultsThe overall positive rate of HPV E6,E7 expression in NSCLC was 39.5% (17/43),which had a significant difference compared with the data of the benign group(7.4%,2/24)(χ2 =8.657,P<0.05).Among all the NSCLC patients,the HPV positive rate of smokers(53.8%) was statistically higher than that of nonsmokers(19.0%),which showed a positive correlation between HPV infection and cigarettes(χ2=5.79,P<0.05).However,no significant difference had been found among HPV infection and other clinical or pathological factors such as classification of histology (positive rate of adenocarcinoma was 43.5%,and squamous carcinoma was 35.0%,χ2=0.322,P>0.05),age(under the age of 50,positive rate was 33.3%,those older than 50 was 40.5%,corrected χ2≈0.000,P>0.05) or gender(male had a positive rate of 40.0%,female 30.8%,corrected χ2=0.054,P>0.05).ConclusionsHPV E6,E7 may have etiologic sense for NSCLS,the HPV positive rate of smokers is higher than that of nonsmokers,and the HPV positive rate of different histological types and sex has no significant difference between two groups.
郑中文 吴健 杨惠玲. 人乳头瘤病毒E6E7原癌蛋白在客家地区非小细胞肺癌中表达的意义[J]. 中华诊断学电子杂志, 2015, 3(1): 7-11.
Zheng Zhongwen,Wu Jian,Yang Huiling. Significance of the expression of human papilloma virus proto-oncogene proteins E6E7 in non-small-cell lung cancer in Hakka region. zhzdx, 2015, 3(1): 7-11.
