Abstract：ObjectiveTo investigate the diagnostic value of N-epsilon-carboxy methyl lysine (CML) in patients with acute coronary syndrome (ACS).MethodsA total of 160 patients who were hospitalized from department of cardiology,Jiangsu University affiliated hospital (120 patients) and department of cardiology,Jintan Hospital affiliated to Jiangsu University (40 patients) were divided into control group (group A,n=40),unstable angina pectoris group (group B,n=40),non-ST-segment elevation myocardial infarction group (group C,n=40) and ST-segment elevation myocardial infarction group (group D,n=40).All patients received venous blood after admission.Serum CML and cardiac troponin I (cTnI) levels were detected respectively.ResultsThe serum levels of CML in patients with ACS were significantly higher than that in group A ［(183.82±57.65)μg/L］,the increased levels of CML in group C ［(806.48±38.60) μg/L］and group D ［(869.37±73.61)μg/L］ were significantly higher than that in group B ［(538.25±48.46)μg/L;F=1238.71,P<0.01］.Besides,the expression of CML was positively correlated with coronary Gensini score (r= 0.43,P<0.05),and the increased CML level in coronary artery was significantly correlated with the severity of coronary artery lesion.The difference among coronary lesion vessels was statistically significant ［single-branch vessel (494.08±56.13）μg/L,double-branch vessel （547.17±43.47）μg/L,three-branch vessel （622.21±42.48）μg/L，F=41.15,P<0.05］.ConclusionsThe level of CML is closely related to the severity of coronary artery disease and it may be used as a complement factor to cTnI in the diagnosis of acute coronary syndrome.
