Diagnosis and treament of mood disorder in the patients with chronic gastritis and helicobacter pylori
Wang Xia1,Chen Yulong2，Zhang Xiaofeng1
1Department of Gastroenterology,The First People′s Hospital of Hangzhou, Hangzhou 310006, China;2Department of Gastroenterology,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052, China
Abstract：ObjectiveTo investigate the diagnosis of mood disorder in patients with chronic gastritis infected with helicobacter pylori (Hp),and explore the effects of different therapies.MethodsThe psychological status of chronic gastritis infected with Hp (two hundred and eighty cases) was analyzed with Hamilton Depression/Anxiety (HAMD /HAMA) Scales.Additionally,the patients with depression or anxiety (ninty-three cases) were randomly divided into three groups:group A received routine and antidepressant treatments,group B received antidepressant treatment and group C received routine treatment.Efficacy was assessed by patients’ perception of overall digestive symptoms and HAMD/HAMA Scales,and the infection of Hp was detected by 13C-urea Breath test (13C-UBT).ResultsThe prevalence rate of depression or anxiety in chronic gastritis with Hp by the worry about cancer was 33.2% (93/280).The positive rate of 13C-UBT was 12.0% （9/30）in group A,89.0% （25/28）in group B,16.7% （5/30） in group C after 8week treatment.The severity of patients’ perception of overall digestive symptoms was significantly improved in group A after 8week treatment（25.3±4.1,11.4±1.6,t=14.1,P<0.05）,partly improved in group B （25.4±3.9,15.3±3.1,t=5.8,P<0.05）,and not improved at all in group C(25.2±4.4,19.8±3.7，t=1.9，P>0.05）.There was significant difference of overall digestive symptoms in group A or B compared with that in group C (t=7.3,5.2;P<0.05),but the difference was not significant between group A and group B（t=2.1,P>0.05）.The total clinical efficiency of mood disorder were 85.0%,81.0% and 38.0%.ConclusionsThe prevalence rate of depression and anxiety is higher in chronic gastritis infected with Hp.Routine treatment is ineffective,and antidepressant treatment is partly effective.The combination of both treatments can effectively improve their somatic and psychiatric symptoms.
王霞1陈玉龙2张筱凤1. 慢性胃炎伴幽门螺杆菌感染患者情绪障碍的临床诊断与治疗[J]. 中华诊断学电子杂志, 2015, 3(3): 214-217.
Wang Xia1,Chen Yulong2，Zhang Xiaofeng1. Diagnosis and treament of mood disorder in the patients with chronic gastritis and helicobacter pylori. zhzdx, 2015, 3(3): 214-217.
