Abstract：ObjectiveTo explore the clinicopathological characteristics of intestinal lymphoid polyposis in adults.MethodsThe histopathological features and immunophenotype of two cases of adult intestinal lymphoid polyposis were studied,relevant literatures were reviewed.ResultsA total of 1 male and 1 female were studied,aged 65 and 46,respectively.In all two cases,identification of the polyposis was incidental during the examination of resected of terminal ileum and ileocecal region due to other diseases.Gross findings were multiple polyps in the terminal ileum,measuring 0.1cm~0.5cm in diameter.Hyperplasia of mucosa-associated lymphoid tissue was noticed microscopically.The polyps were composed of closely aggregated lymphoid follicles.The follicles contained prominent germinal centers surrounded by a mantle of small lymphocytes.Immunohistochemical staining showed the follicles to be composed of CD20(+) and Clyclin D1(-) lymphocytes.Cells in germinal center did not express Bcl-2.ConclusionLymphoid polyposis is a rare benign tumor featuring unique clinicopathological characteristics，and the diagnosis relies on histopathological analysis and some ancillary markers.
