The ultrasonic and clinical features of Kimura′s disease
Wang Feilong1,Lu Zhaotong2,Lu Wei3,Li Chuanhai2,Mo Xiuxin2,Yang Fan1,Zhang Chengzheng1,Li Tong1
1Department of Postgraduated Training Base of Jinan Military General Hospital,Liaoning Medical University,Jinzhou 105101,China；2Department of Thoracic Surgery,Jinan Military General Hospital,Jinan 250031,China；3Department of Thoracic Surgery,the First People′s Hospital of Jining,Jining 272011,China
Abstract：Objective To investigate the clinical features of Kimura′s disease.MethodsThe clinical characteristics，laboratory tests，genetic testing，the features of imaging，bone marrow biopsy and pathology of Kimura′s disease were retrospectively analyzed.ResultsLaboratory tests showed that white blood cell count was 11.65×109/L,eosinophil count was 3.12×109/L,the percentage of eosinophil was 35.6%.Erythrocyte sedimentation rate was 32mm/h,C-reactive protein was 20mg/L.The ultrasound showed that there were several beaded lymph node which were adjacent to blood vessels on the left neck,and the cortical thickened.Thoraco-abdominal CT and bronchoscopy revealed no obvious abnormalities.Bone marrow biopsy showed myeloid and erythroid hyperplasia.A number of beaded lymph node integration into group,with the surrounding tissue adhesion.Histopathological examination showed that lymphoid hyperplasia with follicular hyperplasia and diffuse eosinophilic infiltration on interfollicular.Immunohistochemical staining showed CD3，CD20，CD21 and 80% of Ki-67 of follicular area were positive，Bcl-2 was negative.Conclusions Kimura′s disease is a chronic inflammatory disease characterized by lymphadenia,with high peripheral blood eosinophil count and serum immunoglobulin E (IgE).Its diagnosis relys on physical examination,laboratory tests and imaging findings.Histopathological examination can confirm the diagnosis.
