Abstract：Inflammatory cascades have a major impact on outcome and regeneration after ischemic stroke.High mobility group box B1 (HMGB1),a pro-inflammatory cytokine,contributes to the development of atherosclerosis,ischemic brain injury,and neurovascular repair.Meanwhile,it plays a very different role in stroke.HMGB1 participates in progression of atherosclerosis through vascular endothelial hyperpermeability,harmful inflammatory response and migration of smooth muscle cells.HMGB1 is released by necrotic neuronal cells,not only reverses to injury neuronal cell,but as danger-associated molecular patterns (DAMP) to amplify inflammatory response.On the other hand,astrocyte-derived HMGB1 induces the promotion of endogenous EPCs viability and enhances neurovascular repair in post-ischemic.This review mainly focuses on the present research of HMGB1 structure，functions and relationship in stroke.
金聪丽 周海红. 高迁移率族蛋白B1在缺血性脑卒中的作用及研究进展[J]. 中华诊断学电子杂志, 2016, 4(4): 284-.
Jin Congli，Zhou Haihong. Progress of high mobility group box B1 and its relationship in stroke. zhzdx, 2016, 4(4): 284-.
