Diagnostic features of β-catenin mutated activated hepatocellular adenoma and literature review
Ning Chunjing1,2, Wang Shuanglong2, Lyu Bin2
1College of Clinical Medicine, Jining Medical University, Jining 272013, China; 2Department of Ultrasound, Jining NO.1 People′s Hospital, Jining 272002, China
Abstract：ObjectiveTo investigate the diagnostic characteristics of β-catenin mutated activated hepatocellular adenoma (β-HCA). MethodsThe clinical and imageology data of a case of β-HCA pathologically confirmed by puncture biopsy on February 6, 2020 in the Ultrasound Department of Jining NO.1 People′s Hospital were retrospectively analyzed, and the literatures were reviewed. ResultsThe 31-year-old female patient, without any clinical symptoms, was admitted to hospital after physical examination with focal liver lesions. The ultrasonic manifestations of β-HCA were slightly circular higher echo with rich blood supply and uneven internal echo. Contrast-enhanced ultrasound showed rapid enhancement in arterial phase and low enhancement in portal and delayed phases. Histopathological examination revealed hepatocellular adenoma with purpuric hemorrhage. Immunohistochemistry:cytokeratin 8 (CK8) (+++), cluster of differentiation antigen 34 (CD34) (capillary +), CD10(focal +), heat shock protein 70 (HSP70) (focal +), glutamine synthase (GS) (+++), β-catenin (membrane +), and β-HCA was confirmed. ConclusionsβHCA has no specific clinical manifestations. Contrast-enhanced ultrasound can show rapid enhancement in arterial phase, rapid clearance or equal enhancement in portal vein phase, low enhancement or equal enhancement in delayed phase, the final diagnosis depends on histopathological and immunohistochemical analysis.
宁春景 王双龙 吕镔. β-catenin突变激活型肝细胞腺瘤的诊断学特征并文献复习[J]. 中华诊断学电子杂志, 2022, 10(2): 137-142.
Ning Chunjing1,2, Wang Shuanglong2, Lyu Bin2. Diagnostic features of β-catenin mutated activated hepatocellular adenoma and literature review. zhzdx, 2022, 10(2): 137-142.
