吉兰-巴雷综合征诊治的10个步骤(Diagnosis and
management of Guillain-Barré syndrome in ten steps全译）
Sonja E Leonhard，Melissa R Mandarakas，Francisco AA Gondim，Kathleen Bateman，Maria LB Ferreira4，David R Cornblath，Pieter A van Doorn，Mario E Dourado，Richard AC Hughes，Badrul Islam，Susumu Kusunoki，Carlos A Pardo，Ricardo Reisin，James J Sejvar，Nortina Shahrizaila，Cristiane Soares，Thirugnanam Umapathi，王玉忠，Eppie M Yiu，Hugh J Willison，Bart C Jacobs1
Diagnosis and management of GuillainBarré syndrome in ten steps
Sonja E Leonhard1，Melissa R Mandarakas1，Francisco AA Gondim2，Kathleen Bateman3，Maria LB Ferreira4，David R Cornblath5，Pieter A van Doorn1，Mario E Dourado6，Richard AC Hughes7，Badrul Islam8，Susumu Kusunoki9，Carlos A Pardo5，Ricardo Reisin10，James J Sejvar11，Nortina Shahrizaila12，Cristiane Soares13，Thirugnanam Umapathi14，王玉忠15，Eppie M Yiu16,17,18，Hugh J Willison19，Bart C Jacobs1,20
1Department of Neurology, Erasmus University Medical Center, Rotterdam 3015 CE, Netherlands; 2Hospital Universitário Walter Cantidio, Universidade Federal do Ceará, Fortaleza, Ceará 60430370, Brazil; 3Groote Schuur Hospital, University of Cape Town, Cape Town 7925, South Africa; 4Department of Neurology, Hospital da Restaurao, Recife, Pernambuco 52171011, Brazil; 5Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21218, USA; 6Department of Integrative Medicine, Hospital Universitário Onofre Lopes, Universidade Federal do Rio Grande do Norte, Natal 59012300, Brazil; 7UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK; 8International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka 1212, Bangladesh; 9Kindai University Faculty of Medicine, Osaka 5898511, Japan; 10Hospital Británico, Buenos Aires C1280AEB, Argentina; 11Centers for Disease Control and Prevention, Atlanta, GA 30329, USA; 12Department of Neurology, University of Malaya, Kuala Lumpur 50603, Malaysia; 13Hospital Federal dos Servidores do Estado, Rio de Janeiro 20221903, Brazil; 14National Neuroscience Institute, Singapore 308433, Singapore; 15Department of Neurology, Affiliated Hospital of Jining Medical University, Jining 272029, China; 16Department of Neurology, The Royal Children′s Hospital Melbourne, Melbourne, VIC 3052, Australia; 17Neurosciences Research, Murdoch Children′s Research Institute, Melbourne, VIC 3052, Australia; 18Department of Paediatrics, The University of Melbourne, Melbourne, VIC 3052, Australia; 19College of Medicine, Veterinary and Life Sciences, University of Glasgow, Glasgow G61 1QH, UK; 20Department of Immunology, Erasmus University Medical Center, Rotterdam 3015 GD, Netherlands
Abstract：Guillain-Barré syndrome (GBS) is a rare, but potentially fatal, immune-mediated disease of the peripheral nerves and nerve roots that is usually triggered by infections. The incidence of GBS can therefore increase during outbreaks of infectious diseases, as was seen during the Zika virus epidemics in 2013 in French Polynesia and 2015 in Latin America. Diagnosis and management of GBS can be complicated as its clinical presentation and disease course are heterogeneous, and no international clinical guidelines are currently available. To support clinicians, especially in the context of an outbreak, we have developed a globally applicableguideline for the diagnosis and management of GBS. The guideline is based on current literature and expert consensus, and has a ten-step structure to facilitate its use in clinical practice. We first provide an introduction to the diagnostic criteria, clinical variants and differential diagnoses of GBS. The ten steps then cover early recognition and diagnosis of GBS, admission to the intensive care unit, treatment indication and selection, monitoring and treatment of disease progression, prediction of clinical course and outcome, and management of complications and sequelae.
Sonja E Leonhard，Melissa R Mandarakas，Francisco AA Gondim，Kathleen Bateman，M. 吉兰-巴雷综合征诊治的10个步骤(Diagnosis and
management of Guillain-Barré syndrome in ten steps全译）[J]. 中华诊断学电子杂志, 2023, 11(3): 198-211.
Sonja E Leonhard1，Melissa R Mandarakas1，Francisco AA Gondim2，Kathleen Bateman3，Maria LB Ferreira4，David R Cornblath5，Pieter A van Doorn1，Mario E Dourado6，Richard AC Hughes7，Badrul Islam8，Susumu Kusuno. Diagnosis and management of GuillainBarré syndrome in ten steps. zhzdx, 2023, 11(3): 198-211.
