Relationship between angiotensin-converting enzyme gene insertion/deletion polymorphisms and left ventricular hypertrophy in Uygur patients with hypertension and obstructive sleep apnea hypopnea syndrome
1Department of Intensive Care Unit, the Second Affiliated Hospital of Xinjiang Medical University, Urumqi 830063,China; 2Department of Hypertension, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
Abstract：ObjectiveTo explore the association of angiotensin converting enzyme(ACE) gene insertion/deletion (I/D) polymorphism with left ventricular hypertrophy in Uygur hypertension-OSAHS patients. MethodsSeventy-two Uygur hypertension-OSAHS patients without taking ACEI/ARB antihypertensive drugs and newly diagnosed of hypertension in the First Affiliated Hospital of Xinjiang Medical University between January 2015 and December 2016 were selected. All patients underwent polymorphic sleep monitoring, 24h ambulatory blood pressure monitoring, echocardiography, and PCR, agarose gel electrophoresis were applied to determine genotype and allele frequency of ACE gene.To group by computing left ventricular mass index， the differences of genotype and gene frequency were used and the riskfactors for left ventricular hypertrophy were analysed via Logistic regression. ResultsIn hypertension-OSAHS patients, the frequencies of II, ID, DD genotypes were 37.50%，20.83%，41.67%, respectively, and I, D allele frequencies were 48.00%，52.00% in LVH group. In NLVH group, the frequencies of II, ID, DD genotypes were 47.92%，37.50%,14.58%, respectively, and I, D allele frequencies were 67.00%，33.00%. There were significant differences in ACE gene polymorphisms between LVH group and NLVH group in hypertension-OSAHS patients（χ2=6.75，4.70, all P＜0.05）. Logistic regression analysis showed that apnea hypopnea index (AHI)（OR=6.20，95%CI：1.44-26.77, P＜0.05）,DD genotype（OR=4.61，95%CI：1.05-20.31,P＜0.05）were the independent risk factors for LVH in Uygur hypertension-OSAHS patients. ConclusionsThe ACE I/D polymorphisms are associated with the development of left ventricular hypertrophy in Uyghur hypertension-OSAHS patients and the DD genotype Uygur patients are more likely to have left ventricular hypertrophy.
