Analysis of case characteristics of four kinds of antibodypositive patient with myasthenia gravis complicated with rheumatoid arthritis
Sun Zhijuan1, Liu Jingfeng2, Zhang Jingyang1, Hao Hongjun3
1Department of Rheumatology, 2Department of Neurology, Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou 061001, China; 3Department of Neuroimmune, Peking University First Hospital, Beijing 100034, China
Abstract：ObjectiveTo explore the diagnostic features of four antibody-positive patient with myasthenia gravis （MG） combined with rheumatoid arthritis(RA). MethodsThe clinical data of a MG patient with four antibody-positive combined with RA in the Rheumatology Department of Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine were retrospectively analyzed,and related literatures were reviewed. ResultsThe patient was diagnosed with MG and RA with ptosis, fatigue, dysphagia, symmetrical polyarticular swelling and pain four years and six months ago. He was given pyridostigmine bromide, prednisone acetate, methotrexate, leflunomide and hydroxychloroquine, and the above symptoms improved. Due to the discontinuation of pyridostigmine bromide and prednisone acetate reduction, the disease recurred. After perfecting the MG-related antibodies examinations, it was found that the acetylcholine receptor (AChR) antibody, the muscle-specific tyrosine kinase (MuSK) antibody, the ryanodine receptor (RyR) antibody, and the acetylcholinesterase (AChE) antibody were positive at the same time. Adjusting the treatment plans to prednisone acetate, cyclosporine and pyridostigmine bromide, the condition was gradually eased. ConclusionFour kinds of antibodies can be detected in patients with MG and RA, suggesting that different antibody-mediated pathogenic mechanisms may exist in autoimmune overlap.
孙志娟 刘景峰 张静阳 郝洪军. 四种抗体阳性重症肌无力合并类风湿性关节炎的病例特征分析[J]. 中华诊断学电子杂志, 2021, 9(1): 30-34.
Sun Zhijuan1, Liu Jingfeng2, Zhang Jingyang1, Hao Hongjun3. Analysis of case characteristics of four kinds of antibodypositive patient with myasthenia gravis complicated with rheumatoid arthritis. zhzdx, 2021, 9(1): 30-34.
