Progress in studies on the correlation between IGF-1 level and thyroid diseases in diabetic patients
Luan Ruowei1, Zhang Mei2
1College of Clinical Medicine, Jining Medical University,Jining 272013,China; 2Department of Endocrinology, Affiliated Hospital of Jining Medical University, Jining 272029, China
Abstract：Insulinlike growth factor 1 (IGF-1) is one of the most important and extensive functional cytokines the body. It can promote growth and development, substance metabolism, cell differentiation and proliferation. The amino acid sequence of IGF-1 is homologous to insulin, so it has hypoglycemic effect similar to insulin. Previous studies have shown that serum IGF-1 levels are lower in the people with diabetes than those in the people without diabetes. At the same time, IGF-1 can stimulate thyroid function directly or indirectly, and it can affect iodine uptake and organic synthesis together with the thyrotropin (TSH), leading to abnormal thyroid function. In recent years, the incidence of thyroid disease in patients with diabetes is increasing year by year. This paper reviews the research progress of the correlation between IGF-1 levels and thyroid diseases in diabetic patients.
栾若蔚 张梅. 糖尿病患者中胰岛素样生长因子1水平与甲状腺疾病的相关性研究进展[J]. 中华诊断学电子杂志, 2022, 10(2): 109-112.
Luan Ruowei1, Zhang Mei2. Progress in studies on the correlation between IGF-1 level and thyroid diseases in diabetic patients. zhzdx, 2022, 10(2): 109-112.
