Abstract：Alzheimer′s disease(AD) is a neurodegenerative disease which is the most common form of dementia in the elderly. Misfolding and accumulation of tau proteins and β-amyloid (Aβ) (1-42) cause progressive neuronal loss. In recent researches, the biological markers of AD, tau proteins and β-amyloid protein, could reflect its pathological features as including neuronal fiber tangles (NFTs) and senile plaque (SP) deposition in neurons. Autophagy is a highly conserved lysosomaldependent degradation process that supplies energy to the body, cleans up metabolic waste, and balances immune inflammatory responses.In this review, we concluded the pathology of tau proteins and Aβ protein and the autophagic mechanisms in AD.
乔蕾 孙寅轶 曲忠森. tau蛋白和β-淀粉样蛋白在阿尔茨海默病病理过程中作用及自噬机制的研究概况[J]. 中华诊断学电子杂志, 2019, 7(2): 94-97.
Qiao Lei, Sun Yinyi, Qu Zhongsen. Research situation of tau proteins and β-amyloid protein in the pathological process and autophagic mechanisms in Alzheimer′s disease. zhzdx, 2019, 7(2): 94-97.
