Abstract：Alzheimer′s disease (AD) is a common neurodegenerative disease which is closely related to aging. AD is becoming more common with the aggravation of population aging, the incidence rate of it increases year by year. Ferroptosis is a type of cell death distinct from apoptosis, necrosis, and autophagy. Ferroptosis is distinguished by iron-dependent lipid peroxidation, glutathione depletion, and iron overload. Glutathione peroxidase 4 (GPX4) is a selenoprotein with anti-lipid peroxidation and is a key regulator in ferroptosis. Lipid peroxidation, iron metabolism disruption, and ferroptosis caused by selenium deficiency demonstrate close relationship with AD. This paper summarizes the key mechanisms and research progress of ferroptosis in AD, as well as the prospects of ferroptosis in the treatment of AD.
刘倩 李鑫 刘欣 苑金香. 铁死亡在阿尔茨海默病发病机制中的研究进展[J]. 中华诊断学电子杂志, 2022, 10(3): 211-215.
Liu Qian1, Li Xin1, Liu Xin1, Yuan Jinxiang2. Research progress of ferroptosis in the pathogenesis of Alzheimer′s disease. zhzdx, 2022, 10(3): 211-215.
