Predictive value of creatinine/cystatin C on postoperative complications of advanced epithelial ovarian cancer
Wang Kejun1, Li Jizhen2, Ma Biao3, Xu Huichao4, Shen Hongshan4, Liu Lei5
1Colloge of Clinical Medicine, Jining Medical University, Jining 272013, China; 2Department of Cardiology, Wenshang People′s Hospital, Jining 272500, China; 3Intensive Care Unit, 4Department of Clinical Nutrition, 5Department of General Medicine, Affiliated Hospital of Jining Medical University, Jining 272029, China
Abstract：ObjectiveTo study the predictive value of creatinine/cystatin C (CCR) on complications following surgery for advanced epithelial ovarian cancer (EOC). MethodsFrom January 1, 2017 to October 30, 2020,106 patients with advanced EOC who received surgical care in the Gynecology Department of the Affiliated Hospital of Jining Medical University were the subject of a retrospective cohort research. In order to identify the potential risk factors for postoperative complications, univariate regression analysis was utilized. Multivariate logistic regression analysis was used to determine the independent influencing factors of postoperative complications. The best cutoff value for the CCR was determined using a receiver operating characteristic (ROC) curve. Patients were divided into high and low CCR groups according to the critical value to investigate the relationship between the CCR and postoperative complications. ResultsPostoperative complications occurred in 76 patients (71.70%). Multivariate logistic regression analysis revealed that intraoperative blood loss greater than 300ml (OR=8.53, 95%CI 2.04-35.74) was an independent risk factor for postoperative complications after controlling for relevant confounding variables （P＜0.01）. CCR was an independent protective factor for postoperative complications. Postoperative complications were reduced by 40.00% for every unit rise in CCR (OR=0.60, 95%CI 0.37-0.97, P＜0.05). The preoperative CCR′s optimum cutoff value was 8.165. The overall incidence of postoperative complications in the low CCR group (72/91，79.12%) was significantly higher than that in the high CCR group (4/15，26.67%)（χ2=14.46, P＜0.01）. The incidence of postoperative mild complications in the low CCR group (62/91，68.13%) was significantly higher than that in the high CCR group (3/15，20.00%)（χ2=12.58, P＜0.01）. ConclusionIn patients with advanced EOC after surgery, the preoperative CCR can accurately predict postoperative problems.
王可珺 李吉镇 马标 续慧超 谌红珊 刘雷. 肌酐/胱抑素C对晚期上皮性卵巢癌术后并发症的预测价值[J]. 中华诊断学电子杂志, 2023, 11(1): 49-55.
Wang Kejun1, Li Jizhen2, Ma Biao3, Xu Huichao4, Shen Hongshan4, Liu Lei5. Predictive value of creatinine/cystatin C on postoperative complications of advanced epithelial ovarian cancer. zhzdx, 2023, 11(1): 49-55.
